Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis
نویسندگان
چکیده
منابع مشابه
Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis.
This study aimed to explore how tumor-associated fibroblasts (TAFs) promote the proliferation and angiogenesis of tumor cells via the paracrine mechanism in vitro. Conditioned media (CM) of ovarian TAFs and normal fibroblasts (NFs) were collected. Ovarian cancer cells (OCCs) were treated with 2 mL TAFs-CM and NFs-CM in experimental and control groups, respectively; 20 mM SB431512, a specific sm...
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OBJECTIVE EMT (epithelial to mesenchymal transition) contributes to tumor progression and metastasis. We aimed to investigate the effects of EMT on CDDP resistance in HNSCC (head and neck squamous cell carcinoma)-cells. METHODS EMT was induced using conditioned medium from a tumor cell/fibroblast co-culture. HNSCC cells were alternatively treated with TGF-β1. The response to CDDP was evaluate...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2013
ISSN: 1676-5680
DOI: 10.4238/2013.november.22.14